Basic Information
VIS ID
TVIS10011906
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2297
Orient
+
Integrated sequence
AACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTA| |TAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGA
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
23836015/23493828 (Hg38)
End
23836015/23493828 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1286/Upstream/607449; hsa-let-7a-3/Downstream/1961818;
Nearest TSS
ENST00000624155/Upstream/6848; ENST00000629869/Downstream/19774;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/33081, chr22-CpG: 67/Downstream/27745
Nearby gene
ZDHHC8P1(-91216) ; IGLL1(+79298) ;
Upstream sequence
CCCAGCAGGGCCAGCTCACCCAGGAGCTGAGCGGGAGGGTCTCTCTGCCCTGTAGACACTGGGTTCAGgatcaggagctgagaccccagatcagacagac
Downstream sequence
ctagaccctggctcttcctcttagcagctatgtgagtctccatctctccagttatagtgggaatgatatggggaaccatgtctccatcttattgtaaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate