Basic Information
VIS ID
TVIS10011907
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1922
Orient
+
Integrated sequence
TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA| |AGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAA
Host Sequence
Chromosome
chr3
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
135449484/135730642 (Hg38)
End
135449484/135730642 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1292736; hsa-mir-1224/Downstream/15835234;
Nearest TSS
ENST00000440867/Upstream/597850; ENST00000447251/Downstream/235031;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/933504, chr3-CpG: 47/Downstream/235422
Nearby gene
EPHB1(-470177) ; PPP2R3A(+235031) ;
Upstream sequence
aattgtgtactttaaaagggtgctttttatgttatgtgaattatatctcaataaagctgtcaCACAAAACACAACAAGATAGGGAATCAACCTGAGATGT
Downstream sequence
tggttggaaattattttaagaatgctgaatacagatccccagtctcttctggcttgttggttttctgctgacaggtctgctgttagcctgatggggttaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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