Basic Information
VIS ID
TVIS10011921
Fusion event
HBV-LOC105377369 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1675
Orient
-
Integrated sequence
ACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTC| |TCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTAC
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
112845792/111924636 (Hg38)
End
112845792/111924636 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105377369
Nearest miRNA
hsa-mir-12113/Upstream/1063989; hsa-mir-1243/Downstream/723238;
Nearest TSS
ENST00000502981/Upstream/114942; ENST00000309733/Downstream/148062;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1284984, chr4-CpG: 120/Downstream/220678
Nearby gene
PITX2(-1282513) ; FAM241A(+220761) ;
Upstream sequence
ctcccaaagtgattccactgcaggtggtgccacaagccacattttggtagACGGCAGGTTTCAGAGGACGGACACGTGGCATCCTGTTGACATAGGAAGC
Downstream sequence
TCAAAGAAAAGACACATTTTTGAGCCACTATAAATAAAAAATCATAGAGAAAGTGATATTTAAACTGGCCTGGAAAAAAAGGAAAAATCTAAAATAAACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate