Basic Information
VIS ID
TVIS10011923
Fusion event
HBV-TTC29 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1841
Orient
+
Integrated sequence
TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT| |CATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTG
Host Sequence
Chromosome
chr4
Cytoband
q31.22
Reference genome
GRCh37/hg19
Start
147754595/146833443 (Hg38)
End
147754595/146833443 (Hg38)
Orient
-
Location type
Intronic
Target gene
TTC29
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12113/Upstream/424755; hsa-mir-1305/Downstream/511186;
Nearest TSS
ENST00000502981/Upstream/20413; ENST00000515530/Downstream/100558;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/177833, chr4-CpG: 31/Downstream/112234
Upstream sequence
CTCCACCATGTTTTCCTAGTGCAAGATTTTTCCTTTTCGCATATTTAAATTCATTTCATTGACAACAGGCATTGCAAACTCAATGATTTCTCTGTGCCAA
Downstream sequence
AGATCTGGAAAGGTTATGGTGAGCCACAGCCACTGAAGCGTACTACATATTTCTGTGCTGTCTGCTTTCTTAACTTGTGAGATGTGACCCGATTTTTTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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