Basic Information
VIS ID
TVIS10011932
Fusion event
HBV-LOC105377731 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1726
Orient
-
Integrated sequence
CGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTT| |AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
172711899/173284896 (Hg38)
End
172711899/173284896 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
LOC105377731
Nearest miRNA
hsa-mir-10397/Upstream/369738; hsa-mir-12118/Downstream/18834;
Nearest TSS
ENST00000502646/Upstream/49539; ENST00000523205/Downstream/39390;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/837, chr5-CpG: 19/Downstream/9048
Nearby gene
NKX2-5(-49584) ; STC2(+29827) ;
Upstream sequence
GGCCGCTGGCCTGATCCGGAGACCCAGGGCTGCCTCCAGGTCCGGACGCGGGGCGTCGGGCTCCGGGCACCACGAATGCCGGACGTGAAGGGGAGGACGG
Downstream sequence
atcagtccatccatccatccatccacccatcccttcatccatccaaccatccacccattcatctacgcatccatccactcacccacccatcattcaacta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate