Basic Information
VIS ID
TVIS10011936
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr6
Cytoband
p23
Reference genome
GRCh37/hg19
Start
14359079/14358848 (Hg38)
End
14359079/14358848 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6A
Nearest miRNA
hsa-mir-3691/Upstream/3919054; hsa-mir-10398/Downstream/1782708;
Nearest TSS
ENST00000381078/Upstream/73394; ENST00000434947/Downstream/34440;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/147335, chr6-CpG: 113/Downstream/885798
Nearby gene
CD83(-221931) ; JARID2(+887127) ;
Upstream sequence
GAGTTGTAGTGAATGTAATTACAGTGGCAAAATGATAAACACATAGCTATTTTGCCTGGTAATATTATGTATTTTAACAGGTTTATTTGTTCAACAGTTC
Downstream sequence
GGAACCCTTCCTGATGGATGCATACTTCAGGTTCTATCTGTTTACAAAAGGCTGATTTTCCCATCCTTGATATTTCTCCTAGAAATTAGGTCCTGGAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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