Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011938
Fusion event
HBV-FARS2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2056
Orient
+
Integrated sequence
TTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACC| |ATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGT
Host Sequence
Chromosome
chr6
Cytoband
p25.1
Reference genome
Start
End
5489836/5489603 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-3691/Upstream/341281; hsa-mir-10398/Downstream/679701;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/227901, chr6-CpG: 29/Downstream/361774
Upstream sequence
gagacagtacctgagtcgatgctgaatatcagggcaagactttgaggttaatatttgacaaaagaaaagagggaggcacaacccgacagcataaaattca
Downstream sequence
ATGCTTCCATCTCTTTCCTTCTCTCTACGCACGACGCCATTACTTCAGTTCTGGGCTTTATCACTCTTTCCTGTACAGGCATATTAGTCTTCAGATAGGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.