VISDB Viral Integration Site DataBase

VIS ID

TVIS10011940

Fusion event

HBV-CUX1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1731

Orient

-

Integrated sequence

ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC

Chromosome

chr7

Cytoband

q22.1

Reference genome

Start

End

101548877/101905597 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-877-3p ; hsa-mir-455-3p ; hsa-mir-18b-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-218-5p

Nearest miRNA

hsa-mir-10525/Upstream/746042; hsa-mir-10399/Downstream/387506;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/87847, chr7-CpG: 20/Downstream/10525

Nearest cancer related gene

CUX1(TSG, No orient, 0)

Upstream sequence

TGTGTATGCAGTCTATACACAATGCCTGATGGACTGAGGCAGTAAATTAAATGCAGCGGTGAAAACACGACCAACCTACAGTTGAACTCAAAGTGAGAAA

Downstream sequence

GTACTGGGGACCAAGATCCACCCTCGTGGTGAGAAAACCACACCATAAATAAACACAGCCACCATACGCCGTGAGATCTGGCCAAGAGGTTTCCTTCTGT