Basic Information
VIS ID
TVIS10011944
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1923
Orient
+
Integrated sequence
TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA| |GAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAG
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
16871611/16831987 (Hg38)
End
16871611/16831987 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-339/Upstream/9764942; hsa-mir-10399/Downstream/1295233;
Nearest TSS
ENST00000635602/Upstream/26907; ENST00000645559/Downstream/1446;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/77512, chr7-CpG: 26/Downstream/19157
Nearby gene
AGR2(-26873) ; AGR3(+27419) ;
Upstream sequence
CTCTCCTAAAATCTGAGTATCAGAGAAAAAATTATTGCAGAATTGTTTGTTTTTCTTCATTAGTAGGTAATTAATATTTTACCTGGACAGGTTGACAATT
Downstream sequence
tatatgaaaccacaaaagaccagaagagccgaagctatcctgagcaaagagaacaaaattggaggaaccacattacctgacttcaagttatactatagag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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