VISDB Viral Integration Site DataBase

VIS ID

TVIS10011946

Fusion event

HBV-POU6F2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1820

Orient

-

Integrated sequence

TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT

Chromosome

chr7

Cytoband

p14.1

Reference genome

Start

End

39075999/39036399 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-505-5p ; hsa-mir-545-3p ; hsa-mir-3120-3p ; hsa-mir-7850-5p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa

Nearest miRNA

hsa-mir-1183/Upstream/2116967; hsa-mir-10399/Downstream/4114496;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/60070, chr7-CpG: 58/Downstream/377517

Nearest cancer related gene

POU6F2(TSG, No orient, 0)

Upstream sequence

ttctaaatataattatggatttttctatttcttcttttagttctatcagtttgtctcatgtatttcaaatctctgttaggtgcatacatatttacggatt

Downstream sequence

ACCTGCAAAGTATGGAAAGAATGATTTAATTATAATTAATTGTCATGAATGATGCCATTTACATTTATTCTACATAATACTAAATACAAAATTTAACTTT