Basic Information
VIS ID
TVIS10011959
Fusion event
HBV-LOC105375932 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1675
Orient
-
Integrated sequence
ACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTC| |TCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTAC
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
84601288/83689053 (Hg38)
End
84601288/83689053 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375932
Nearest miRNA
hsa-mir-12123/Upstream/3447580; hsa-mir-10400/Downstream/7516432;
Nearest TSS
ENST00000518652/Upstream/285295; ENST00000523678/Downstream/223660;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1846812, chr8-CpG: 49/Downstream/495471
Nearby gene
SNX16(-1846767) ; RALYL(+494165) ;
Upstream sequence
TGTTACTCATATCATTACTATTGTATTTAAGTACGACAAATACTAAAAATGAGAAAAATTGTAAAAAAAAGTTCAAATGCATAAAATAGGTAACGTATTA
Downstream sequence
caacgcaaggtgtagaaaccctaacaTTTTTACAAAAGGAATGTTAAATGATAGAGATAGACATGCACTATTTCACTAACAGGTTTCAAAAAGAGCAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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