Basic Information
VIS ID
TVIS10011960
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1831
Orient
+
Integrated sequence
CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC| |TCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGG
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
103753121/100990839 (Hg38)
End
103753121/100990839 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/2761622; hsa-mir-12126/Downstream/5610089;
Nearest TSS
ENST00000422679/Upstream/412760; ENST00000494890/Downstream/37870;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/391809, chr9-CpG: 96/Downstream/37491
Nearby gene
CAVIN4(-402948) ; PLPPR1(+37910) ;
Upstream sequence
tcagaatacaattgaaaattttagtgaaattcttctatgcctgtgcatacgcacacacatgataaacacacaatgaatgctacgtatgattttgcaaact
Downstream sequence
CTTTTGCAAACTCTCCTGAAATGACTTCAGCAGGATTTGCCACTATTGTGACTCCCCTTGACTTTAGGAGAGCCTCTAAACCTTGGGTTGGCAAGTTTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate