VISDB Viral Integration Site DataBase

VIS ID

TVIS10011961

Fusion event

HBV-PAPPA integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1812

Orient

-

Integrated sequence

AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCG

Chromosome

chr9

Cytoband

q33.1

Reference genome

Start

End

118945472/116183193 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA9E ; FRA9B

Target gene

miRNAs that regulate target gene

hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-mir-490-3p ; hsa-mir-214-3p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-141-3p

Nearest miRNA

hsa-let-7a-1/Upstream/1973664; hsa-mir-12126/Downstream/4061786;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/28297, chr9-CpG: 37/Downstream/504001

Upstream sequence

CCAGCTCTAAAAATTTATATGCAAAGAATTTACTTTTAGTTCTTCTATATCCATAGCAATATATATCATTTCCAATATTTGTACTGTAAGTCCCAGTAAC

Downstream sequence

CAGAGAACAGCATTGTGTGTCCTGTATAGAGATCCTCAGAGGAGACAGAACCTAAGCATGCAAGAGTTGCGAATGACATAAGGCATCTAATTCCAATCAA