Basic Information
VIS ID
TVIS10011965
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
285
Orient
-
Integrated sequence
ACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGG| |GGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTC
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
End
185664789/185695657 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/5257267; hsa-mir-1182/Downstream/7020671;
Nearby gene
GS1-279B7.1(-360618) ; HMCN1(+38894) ;
Upstream sequence
TATAGATTCTTTCAAAAAGAAAGGTAGAATGGATGAACATTGTCTGAAAATAACTTGAGACTTATGATTGGATATTTAGAAATTTATAATTCAGATTCAG
Downstream sequence
TGCACTTCAGAATGTTTTCTCTCTGAGACCCTTGTTTACCACTTTTTGTTCAACTACCTTGAAAAATTAGTTTTGGGTTTCTTAAGGATTGAAGAGACTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate