VISDB Viral Integration Site DataBase

VIS ID

TVIS10011968

Fusion event

HBV-DNAJC11 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2055

Orient

+

Integrated sequence

TTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCAC| |CATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAG

Chromosome

chr1

Cytoband

p36.31

Reference genome

Start

End

6761116/6701056 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-193b-3p ; hsa-mir-324-5p ; hsa-mir-218-5p ; hsa-mir-5196-5p ; hsa-mir-323a-5p ; hsa-mir-4747-5p ; hsa-mir-671-5p ; hsa-mir-6134 ; hsa-mir-4786-3p ; hsa-mir-6858-3p ; hsa-mir-4709-3p ; hsa-mir-3689d ; hsa-mir-6851-5p

Nearest miRNA

hsa-mir-12136/Upstream/271160; hsa-mir-101-1/Downstream/2165446;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/75276, chr1-CpG: 96/Downstream/179

Nearest cancer related gene

DNAJC11(TSG, No orient, 0)

Upstream sequence

AGGAGTGTAGTGGGGCCCTACTACTGCCAGGCTATGTGAGACTCTCTCATGTTATCTTTTATTCGTTGAGGAGACAGGGTACAAGTGCTTGGTGTGAATG

Downstream sequence

TTGAAGCTGTTGTTAGGGCACCACTTTTCTGGCCTAGGGCTTCTTCCTAATCTGCAGCCTCCGAGCCGAGGGTCTGTGTCCCGGAGGCTCTGCCTGCAAT