Basic Information
VIS ID
TVIS10011973
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
168
Orient
+
Integrated sequence
CTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATC| |ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42528075/41712132 (Hg38)
End
42528075/41712132 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6070880; hsa-mir-107/Downstream/1285431;
Nearest TSS
ENST00000439456/Upstream/3258951; ENST00000442306/Downstream/473207;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2769026, chr10-CpG: 184/Downstream/398901
Nearby gene
LOC441666(+299239) ;
Upstream sequence
atacacgcaacacaaagaagttactgagaattcttctgtctagcattatatgaagaaatcccgtttccaacgaaggcctcaaagaggtccaaatatccac
Downstream sequence
ttgcagactttacaaacagagtgtttccaaactaatctatgaaaagaaaggttaaattctgtgagttgaatgcacacatcaaaaagcagtttctgaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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