Basic Information
VIS ID
TVIS10011989
Fusion event
HBV-LOC105372063 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2127
Orient
-
Integrated sequence
AGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAAT| |TTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCA
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
32989120/35409156 (Hg38)
End
32989120/35409156 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
LOC105372063
Nearest miRNA
hsa-mir-1-2/Upstream/5110196; hsa-mir-122/Downstream/182581;
Nearest TSS
ENST00000575820/Upstream/2628; ENST00000586725/Downstream/57596;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/31714, chr18-CpG: 53/Downstream/88425
Nearby gene
ZNF396(-31819) ; INO80C(+59171) ;
Upstream sequence
GGCACCCCTCCAGCCACACccaccagccattgcaataccttggtaaatagttctttgccctgaatccttctctgcttgaaagaacaagtggtttctgttc
Downstream sequence
tcagactgcaccttgattgatGGGTGCAGGGGCTTCACCATCTGGAAAGCTCTCCCCAGGCAAGTGGGGTGCACAGCCCAGCCAAACCACAGTCATCATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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