VISDB Viral Integration Site DataBase

VIS ID

TVIS10011995

Fusion event

HBV-ZC3H8 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

942

Orient

+

Integrated sequence

AACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAG| |AATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGG

Chromosome

chr2

Cytoband

q14.1

Reference genome

Start

End

112980705/112223128 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2B

Target gene

miRNAs that regulate target gene

hsa-mir-186-5p ; hsa-mir-218-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-4327 ; hsa-mir-6499-3p ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-1247-3p ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-34b-3p ; hsa-mir-665 ; hsa-mir-6807-5p ; hsa-mir-7160-5p

Nearest miRNA

hsa-mir-1285-2/Upstream/451994; hsa-mir-10b/Downstream/1359831;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/35683, chr2-CpG: 67/Downstream/31403

Upstream sequence

tgttctcactcataggtgggaattgaaccataagaacatttggacacagggtggggaacatcacacactggggcctgtcgtggggtgggggagtggggag

Downstream sequence

ggatagcattaggagatatacctaatgtaaatgacgagttaacaggtgcagcacaccaacatggcacatgtatacatatgtaacaaacctgcacgttgtg