Basic Information
VIS ID
TVIS10012001
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2370
Orient
+
Integrated sequence
AGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCT| |AGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCAT
Host Sequence
Chromosome
chr3
Cytoband
q24
Reference genome
GRCh37/hg19
Start
145454372/145736585 (Hg38)
End
145454372/145736585 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/11298679; hsa-mir-1224/Downstream/5829291;
Nearest TSS
ENST00000440867/Upstream/1762977; ENST00000482351/Downstream/203327;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1763148, chr3-CpG: 97/Downstream/424058
Nearby gene
DIPK2A(-1743162) ; PLOD2(+332856) ;
Upstream sequence
gttgagagagtaacagtaggcccatgtgctataaccctcaacaatgtggaagagaaaacccaagggggtgccactgagtaaaacaaggaagggaggcagt
Downstream sequence
CCTAATCTCTTATATTCTCTCAAGGGCCATAGAGACCAAGAGTGTGGTTTATTTTTGAGGAAAGGGGCATTACCTTACAAAAAAAAAAAAAAAAACAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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