VISDB Viral Integration Site DataBase

VIS ID

TVIS10012005

Fusion event

HBV-SLIT3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

397

Orient

-

Integrated sequence

TGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTA| |TCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTC

Chromosome

chr5

Cytoband

q34

Reference genome

Start

End

168125130/168698125 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-218-2-3p ; hsa-mir-218-5p ; hsa-mir-1343-3p ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-214-3p ; hsa-mir-24-3p ; hsa-mir-3074-5p ; hsa-mir-3619-5p ; hsa-mir-3690 ; hsa-mir-4254 ; hsa-mir-4291 ; hsa-mir-4511 ; hsa-mir-6077 ; hsa-mir-646 ; hsa-mir-6783-3p ; hsa-mir-7152-5p ; hsa-mir-7-5p ; hsa-mir-761 ; hsa-mir-922

Nearest miRNA

hsa-mir-10397/Upstream/137152; hsa-mir-10523/Downstream/70021;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/118212, chr5-CpG: 94/Downstream/602300

Upstream sequence

TGGGGCCATACATCCCCACTGGTTAAGCAGAAGACCAAGTTGGCCTCTGAAAGAAGTAAGCGTAGGAGCAGTGGCACTAACAAATGCCTTTTGTCTGCTG

Downstream sequence

TTTTGTGAGCAGGCAATGCAGCAAGATTAGAGAAGCATGTGTATGAAGAGGCTGGTGATGCTGATGACTAAGACCtgttatgggttgaattgtgttcccc