Basic Information
VIS ID
TVIS10012013
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1029
Orient
-
Integrated sequence
CAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTT| |TTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAA
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
136312869/137230710 (Hg38)
End
136312869/137230710 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/679750; hsa-mir-105-1/Downstream/1437001;
Nearest TSS
ENST00000429181/Upstream/199036; ENST00000478471/Downstream/333215;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/177600, chrX-CpG: 49/Downstream/196407
Nearby gene
GPR101(-199036) ; ZIC3(+335477) ;
Upstream sequence
AAAAGCAGTTGGGCTTGATGAGACCCTATCCAGCCCCTTCCCATCTACTCACCCTGATGCCCATGGTTATAGTCATTATCAAAATCATTCCCCTGGAAGT
Downstream sequence
cactgtgcATATCCTTATTTTCTTTACTCATTTAAGCACTTgaatttatccactttttcctgtctccactgtcaccctagctcaagtcatcatcaatctc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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