VISDB Viral Integration Site DataBase

VIS ID

TVIS10012020

Fusion event

HBV-DYNC2H1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1970

Orient

+

Integrated sequence

CCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTT| |CTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGG

Chromosome

chr11

Cytoband

q22.3

Reference genome

Start

End

103283502/103412774 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-let-7a-5p

Nearest miRNA

hsa-mir-10392/Upstream/1892869; hsa-let-7a-2/Downstream/437132;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/320454, chr11-CpG: 43/Downstream/623903

Upstream sequence

AAAATGCTAGTGGATCCTGTGTCTTTTAATAATTTTCAAAACTGTTTAATCATTTTGAAATCATTTTTTGATCACTGACCACCTTAAAAATTGAAGAGGA

Downstream sequence

AGGATGTACTTTCTTAAAATATGTTCATACATATACATATAGAACTTTATTATATAATTTTGAGATGTATGAAGTTAATATCTTCTTTGCTATCCTGGTT