Basic Information
VIS ID
TVIS10012022
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71313186/71602140 (Hg38)
End
71313186/71602140 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/128572; hsa-let-7a-2/Downstream/470088;
Nearest TSS
ENST00000527297/Upstream/19265; ENST00000526393/Downstream/1213;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/24823, chr11-CpG: 111/Downstream/5034
Nearby gene
KRTAP5-11(-19265) ; FAM86C1(+185371) ;
Upstream sequence
aataaaactgttcccgatatccgtgggggagaagatatgtctcccaatatcgcagaaagtgtacacccctctatgatgttactcctaatagccagggggt
Downstream sequence
agaggatgacattatggaaaatagcgcagtgggtgtacatcccttcggtcatgttgttccgaatatcctgtgtgggagcggatgttacgactcccaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate