Basic Information
VIS ID
TVIS10012026
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
114913214/114147739 (Hg38)
End
114913214/114147739 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1267/Upstream/884740; hsa-mir-4502/Downstream/96766;
Nearest TSS
ENST00000623511/Upstream/15128; ENST00000643687/Downstream/6952;
Nearest CpG islands
chr13-CpG: 40/Target, None/Upstream, None/Downstream
Nearby gene
RASA3(-15119) ; CDC16(+87148) ;
Upstream sequence
GCCCCCGAGGAGACCCCAGAACCGACCCAGCCCCCGAGGAGATCCCAGAACCGACCCAGCCCCCGAGGAGATCCCACAACCGACCCAGCCCCCGAGGAGA
Downstream sequence
CCCCAGAACCGACCCAGCCCCCGAGGAGATCCCAGAACCGACCCAGCCCCCGAGGAGATCCCACAACCGACCCAGCCCCCGAGGAGATCCCACAACCGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate