Basic Information
VIS ID
TVIS10012028
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2310
Orient
+
Integrated sequence
TCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAAT| |GCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAAT
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
114914008/114148533 (Hg38)
End
114914008/114148533 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1267/Upstream/885534; hsa-mir-4502/Downstream/95972;
Nearest TSS
ENST00000623511/Upstream/15922; ENST00000643687/Downstream/6158;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/551, chr13-CpG: 16/Downstream/528
Nearby gene
RASA3(-15913) ; CDC16(+86354) ;
Upstream sequence
AGTTACTAGGATGAGTTACAGCACTATTTATTCAAAACTCTGAGAGGCCCGTGTTACTGCTAATTCCAATTTTAACTTTTCTTCCAGAATGGCAGGAAGC
Downstream sequence
GATGAGGGCAGCTGAGGTTTCCAGAGCTCGTGTGTAGCAGGCGCCACGGCTAGTGCATCATGTGAAATTATGTTGCTTTTCTCAACTGTGAGGTGGGGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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