Basic Information
VIS ID
TVIS10012029
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2741
Orient
+
Integrated sequence
CCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTA| |GACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGA
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
48008832/47434697 (Hg38)
End
48008832/47434697 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-2276/Upstream/3238497; hsa-mir-1267/Downstream/2561718;
Nearest TSS
ENST00000623511/Upstream/537621; ENST00000423869/Downstream/401259;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/637348, chr13-CpG: 53/Downstream/566248
Nearby gene
HTR2A(-537621) ; SUCLA2(+507959) ;
Upstream sequence
gcattttttcctgtgttttttggctgcataaatgtcttcttttgagaagtgtctgttcatatccttcgcccactttttgatggggttgtttgtttcttgt
Downstream sequence
aaatctgtttgagttcattatagattctggatattagccctttgtcagatgagtaggttgcaaaaattttctcccattctataggttgactgttcactct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate