Basic Information
VIS ID
TVIS10012031
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr13
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
98184081/97531827 (Hg38)
End
98184081/97531827 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA13D
Nearest miRNA
hsa-mir-1297/Upstream/1104535; hsa-mir-1267/Downstream/676697;
Nearest TSS
ENST00000623511/Upstream/97356; ENST00000604129/Downstream/146136;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/96962, chr13-CpG: 133/Downstream/443978
Nearby gene
RAP2A(-63829) ; IPO5(+421848) ;
Upstream sequence
CATAAGGAATGTGGAAGAAAAAAAGATGACAAATAGAAGCTGTTTATTATCTTTCACTCCCAAGGCCCTACTACAATTATAGAGGGAAAAAATTGCAAAG
Downstream sequence
GCGTAAACAACAAAAACAAAAAATAAAACAGGTGATATCAAGGGCCACGTTTTTTTCATGTTTTTCAAATGCAAAGTAGATGgggattgatttagggatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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