Basic Information
VIS ID
TVIS10012032
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2427
Orient
+
Integrated sequence
ACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGA| |TCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCAT
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
End
62075876/62041972 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/4269620; hsa-mir-11401/Downstream/5160349;
Nearby gene
CDH8(-5137) ;
Upstream sequence
AATTTTCCAGAAGTTTCATACACTCTAGTAATCAGGCAAATAAAAGAAGGTAAGTTGCTCCCTAGGAAGAAATTCTGTTTTGTtcctcactccaccacgg
Downstream sequence
accagctataaggcttttgatgcaaagtgattaaactttcaatggattttaagtttgtgtctccataagagtgcataatacttctttccatcctcagggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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