DGCR2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012041
Fusion event
HBV-DGCR2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1778
Orient
-
Integrated sequence
GCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAG| |GAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAG
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
19072696/19085183 (Hg38)
End
19072696/19085183 (Hg38)
Orient
+
Location type
Intronic
Target gene
DGCR2
miRNAs that regulate target gene
hsa-mir-346 ; hsa-mir-484 ; hsa-mir-23b-3p
Nearest miRNA
hsa-mir-3198-1/Upstream/1104222; hsa-let-7a-3/Downstream/878570;
Nearest TSS
ENST00000624155/Upstream/19279; ENST00000456035/Downstream/36346;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/54777, chr22-CpG: 115/Downstream/36372
Upstream sequence
aagaaaaattctcctgccttggaaAAAAAAAAAAAAACAAAGATggttccactgggaaaacagaaaccatgctaagggatttctaacacgaagggtttaa
Downstream sequence
tacagaaaataggtgctttcaaaacaactggcaaggctatatagtgtgagcaaaagtaaagtgggctaactccccatctaattcccacagtcattgtcaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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