Basic Information
VIS ID
TVIS10012042
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
232
Orient
-
Integrated sequence
AGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCC| |TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
90408778/90359628 (Hg38)
End
90408778/90359628 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3133351; hsa-mir-12124/Downstream/6000336;
Nearest TSS
ENST00000440867/Upstream/1251952; ENST00000478400/Downstream/3551529;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1244671, chr3-CpG: 39/Downstream/3614082
Nearby gene
EPHA3(-877494) ;
Nearest cancer related gene
EPHA3(TSG, -877494) ;
Upstream sequence
gggtgagggtgaggatgaaggttagggttagggttagggttagggttagggttagggttagggttagggttagggttaggggtgtgggtgagggtgagga
Downstream sequence
agattttatgtgaagatatttcctctttcaccataggcctcaaagtgttccaaacatccacttgcaggttctacaaaagagtgtttccaaactgctcaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate