Basic Information
VIS ID
TVIS10012045
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1956
Orient
+
Integrated sequence
TCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTT| |TTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACC
Host Sequence
Chromosome
chr4
Cytoband
q28.3
Reference genome
GRCh37/hg19
Start
132609196/131688041 (Hg38)
End
132609196/131688041 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/6180734; hsa-mir-1305/Downstream/11655419;
Nearest TSS
ENST00000502981/Upstream/202084; ENST00000507933/Downstream/85261;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2594297, chr4-CpG: 27/Downstream/35151
Nearby gene
PCDH10(+1461274) ;
Nearest cancer related gene
PCDH10(TSG, +1461274) ;
Upstream sequence
TGAATACCCTAGTCAGGACATTAATTCTTAAGTATATTGTATGAAAGTGTTTAGTCATAAACAAATAAACTTTCTTTTTCTAGAATAAACTCCAAATCCA
Downstream sequence
ctatgcctttgtcataactattgcctcataaatagcatgcatttagctacacacttcatactattgcaattcaaatattgtgaaataccaactcaattta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate