VISDB Viral Integration Site DataBase

VIS ID

TVIS10012046

Fusion event

HBV-NR3C2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1853

Orient

-

Integrated sequence

ATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTC| |ATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCG

Chromosome

chr4

Cytoband

q31.23

Reference genome

Start

End

149038524/148117373 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-19b-3p ; hsa-mir-135a-5p ; hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-944 ; hsa-mir-548i ; hsa-mir-301b-3p

Nearest miRNA

hsa-mir-12113/Upstream/334705; hsa-mir-1305/Downstream/4371954;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/384606, chr4-CpG: 294/Downstream/324687

Upstream sequence

TGTAATATTTTAGCTTTCAGCATCACAATTAAATAATAATTAGTTAATGAGTTCAGTTCACTGCACTTGTGCAGTATATAAAAAGGTAAACTAATGTTTT

Downstream sequence

ACTCTGCCCTCGCTGCTGCCATTGTGTGCCACCTGCCATTGCCTGCCTTTCAGCCTCTTGGTGACTGCTCTTAGGGGAGCAGGAATGACACTGGAGGTAA