Basic Information
VIS ID
TVIS10012047
Fusion event
HBV-LOC107984041 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
101445113/100997237 (Hg38)
End
101445113/100997237 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107984041
Nearest miRNA
hsa-mir-10398/Upstream/1872541; hsa-mir-1202/Downstream/5786888;
Nearest TSS
ENST00000381078/Upstream/115766; ENST00000358361/Downstream/401551;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/115662, chr6-CpG: 36/Downstream/396312
Nearby gene
ASCC3(-115889) ; GRIK2(+401748) ;
Upstream sequence
atgcctgtaatcccagcattttgaaaggccgaggcgggcagatcacgaggtcagaagatggagaccatcctggctaacgtggtgaaaccctgtctctact
Downstream sequence
TGTCATTACTGATTTTACACCTTGTGATAGCAATAACTTATGGTGGCAGATTTCAGAACTTCCCCTGGTATTTTATGGTTTGTGTGTATGTCTTTCAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate