Basic Information
VIS ID
TVIS10012048
Fusion event
HBV-LOC107984041 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
101445119/100997243 (Hg38)
End
101445119/100997243 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107984041
Nearest miRNA
hsa-mir-10398/Upstream/1872547; hsa-mir-1202/Downstream/5786882;
Nearest TSS
ENST00000381078/Upstream/115772; ENST00000358361/Downstream/401545;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/115668, chr6-CpG: 36/Downstream/396306
Nearby gene
ASCC3(-115895) ; GRIK2(+401742) ;
Upstream sequence
gaagatggagaccatcctggctaacgtggtgaaaccctgtctctactaaaaatacaaaaaattaaaaaaaaaaaaagaaaaaaatacagaaaattagccg
Downstream sequence
TACTGATTTTACACCTTGTGATAGCAATAACTTATGGTGGCAGATTTCAGAACTTCCCCTGGTATTTTATGGTTTGTGTGTATGTCTTTCAGAGGCCCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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