VISDB Viral Integration Site DataBase

VIS ID

TVIS10012049

Fusion event

HBV-MDGA1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1792

Orient

-

Integrated sequence

CGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCAT| |AAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTG

Chromosome

chr6

Cytoband

p21.2

Reference genome

Start

End

37645334/37677558 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-210-3p ; hsa-mir-6738-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-18a-3p ; hsa-mir-1237-3p ; hsa-mir-6793-3p ; hsa-mir-8064 ; hsa-mir-8485 ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-324-3p ; hsa-mir-1913

Nearest miRNA

hsa-mir-1236/Upstream/122136; hsa-mir-10398/Downstream/1396756;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/18888, chr6-CpG: 280/Downstream/18427

Upstream sequence

AGAGAAAGAAGAATGGCCCAATTAATTCCACTGGGCCAAAAGTTCTTCAAACTGGATATCACAAGACTGCACTTTCAAGATCTCTCAATCTTTCTTTCCA

Downstream sequence

ATAAAGGCAGCCGAGAAAGCAGAACAGACCACTGTTTACTGCTATGTAAAAATATATTGACAGGTATGGGCAGGGAGTTTAGAATGAATGGTTAATGTTT