Basic Information
VIS ID
TVIS10012055
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1941
Orient
+
Integrated sequence
CATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTG| |GAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGC
Host Sequence
Chromosome
chr8
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
25443052/25585536 (Hg38)
End
25443052/25585536 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/240062; hsa-mir-10400/Downstream/1463317;
Nearest TSS
ENST00000518652/Upstream/105844; ENST00000517964/Downstream/100262;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/126024, chr8-CpG: 32/Downstream/454148
Nearby gene
CDCA2(-77627) ; EBF2(+256194) ;
Upstream sequence
caaggatgtgaagcaataggaactgtaatttattgctggtgggaatgcaaattggtgctgtcacttcggaagacagtttggctgtttcttacaaaaaata
Downstream sequence
TGTCAGGAAGCTATGCATACTTTCTTGGTTAGAACAACTATGTAAAAGATTTTTTTTTTTTGAGGGGCTAGGAAGCTGGAGCTATTGTTGAGAAGCAGCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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