Basic Information
VIS ID
TVIS10012058
Fusion event
HBV-REXO1L2P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
-
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
86750013/85737784 (Hg38)
End
86750013/85737784 (Hg38)
Orient
+
Location type
downstream
Target gene
REXO1L2P
Nearest miRNA
hsa-mir-12123/Upstream/5496311; hsa-mir-10400/Downstream/5467701;
Nearest TSS
ENST00000518652/Upstream/213885; ENST00000517368/Downstream/101921;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/166, chr8-CpG: 130/Downstream/6427
Upstream sequence
TACCTGTTCTGGAGTCCTTGAAGCACCATAATCTTTAAGTAGGAAGACCACACATCCTGGACACAAAGTCAGTATACTCATCTCTTAGTCCATTTATAAA
Downstream sequence
agcacttcggctctggagttacagatctgggttcaaggccaaattccaccacttactaggtttgtaatattggacagataacgtctttgcgcttctacct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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