Basic Information
VIS ID
TVIS10012061
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2793
Orient
+
Integrated sequence
TTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAAC| |AACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCC
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
86812686/85800457 (Hg38)
End
86812686/85800457 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/5558984; hsa-mir-10400/Downstream/5405028;
Nearest TSS
ENST00000518652/Upstream/276558; ENST00000517368/Downstream/39248;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/8583, chr8-CpG: 130/Downstream/1783
Nearby gene
LOC100288562(-8105) ; REXO1L4P(+1866) ;
Upstream sequence
ACATGTTAACACCTACTTCCCCCATAGAAATAAAGCTAATGCTAAAATATGACATTATCGGAAATGACTTATTCTTCTTaattttatagtcaagtactat
Downstream sequence
ttgaggtatgtcccatcagtacctaatttattgagagtttttggcatgaaaggctgttgaattttgtcaaaggccttttctgcatctgttgagataatca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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