Basic Information
VIS ID
TVIS10012067
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1574
Orient
+
Integrated sequence
CTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCG| |GACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACT
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
97596180/98341182 (Hg38)
End
97596180/98341182 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/3277956; hsa-mir-105-1/Downstream/8298632;
Nearest TSS
ENST00000429181/Upstream/698593; ENST00000627700/Downstream/232677;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1655815, chrX-CpG: 23/Downstream/1598154
Nearby gene
DIAPH2(-740583) ; XRCC6P5(+1120420) ;
Upstream sequence
TGATGAGACCCTATCCAGCCCCTTCCCATCTACTCACCCTGATGCCCATGGTTATAGTCATTATCAAAATCATTCCCCTGGAAGTCTGCGGTCCGTTTAT
Downstream sequence
atattgaataggagcggtaaaagtgagaatccttgtctagttccaattcttagaagaaaggctttaggttttcccattcagtataatgttagctgtgtta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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