Basic Information
VIS ID
TVIS10012068
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
677
Orient
-
Integrated sequence
AACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAG| |TTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGC
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
97596540/98341542 (Hg38)
End
97596540/98341542 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/3278316; hsa-mir-105-1/Downstream/8298272;
Nearest TSS
ENST00000429181/Upstream/698953; ENST00000627700/Downstream/232317;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1656175, chrX-CpG: 23/Downstream/1597794
Nearby gene
DIAPH2(-740943) ; XRCC6P5(+1120060) ;
Upstream sequence
cactaaaggcacaatccaaaaaagaaagaattagtaaactcttggaatcattacaatttaaaacttctgctctatgatagacaatgtcaagagaatgaga
Downstream sequence
aggttttctatttcttcctgattcaatgttggtaggttgtatgtgtccaggaatttatccattttctttaggtttttccagtttgttagcatataggtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate