VISDB Viral Integration Site DataBase

VIS ID

TVIS10012072

Fusion event

HBV-MGMT integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1826

Orient

-

Integrated sequence

AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA

Chromosome

chr10

Cytoband

q26.3

Reference genome

Start

End

131284589/129486325 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-181d-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-648 ; hsa-mir-767-3p ; hsa-mir-370-3p ; hsa-mir-661 ; hsa-mir-409-3p ; hsa-mir-124-3p ; hsa-mir-127-3p

Nearest miRNA

hsa-mir-107/Upstream/3666503; hsa-mir-202/Downstream/356974;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/18879, chr10-CpG: 25/Downstream/292861

Upstream sequence

tgctcaggctggagtgcgatggcatgatcttggctcgctgcgacctctgtctcctgggtttaagcaattctcctgccttagcctcccaagtagctgggat

Downstream sequence

tacaggtgcccatcaccacgcctggctaattttttgcatttttagtagagatggggttttgccacgttggccaggctattctcgaactcttgacctcagg