Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012076
Fusion event
HBV-SORBS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
Start
End
97199706/95439949 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-107/Upstream/5847122; hsa-mir-1287/Downstream/624366;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/144258, chr10-CpG: 84/Downstream/120718
Upstream sequence
caggagttcgagacctggtcaacatggtcaacatggtgaaaccccgtctctattaaaaatacaaaaatattagccaggcgtggtgatgggcacctgtaat
Downstream sequence
ctcagctactcgggaggctgaggcaggagaatcacttgaactcaggaggcagagattggagtgagccaagatcacgccactgcactctagcttgggtgac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.