Basic Information
VIS ID
TVIS10012077
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2027
Orient
+
Integrated sequence
TTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTT| |AGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAAT
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104941699/105070972 (Hg38)
End
104941699/105070972 (Hg38)
Orient
+
Location type
Intronic
Target gene
CASP1P2 ; LOC107984381
Nearest miRNA
hsa-mir-10392/Upstream/1220992; hsa-let-7a-2/Downstream/6276785;
Nearest TSS
ENST00000527297/Upstream/25596; ENST00000527177/Downstream/30442;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/906642, chr11-CpG: 31/Downstream/539427
Nearby gene
CARD16(-25648) ; CARD17(+21497) ;
Upstream sequence
GTTTGGAGCACAAGGATGTCTCACATCATGAACACAGCCTCATATTCTTCTCATGTCATCAACAGAAAGTGACCTCATTTAGATTTCATCAGTGAAATGT
Downstream sequence
CCCCCTCCTCACAGTTGGGTTATCCCTCCTCTTACTTTATCGCTGTCCTTCTTGTTTCCCTCAGTAGTCTCCATACATGTGCATGGAGTGGACTGAAGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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