Basic Information
VIS ID
TVIS10012084
Fusion event
HBV-LOC105370251 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1345
Orient
+
Integrated sequence
CCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGT| |TGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTG
Host Sequence
Chromosome
chr13
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
68377564/67803432 (Hg38)
End
68377564/67803432 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
LOC105370251
Nearest miRNA
hsa-mir-1297/Upstream/1585108; hsa-mir-1267/Downstream/9894580;
Nearest TSS
ENST00000623511/Upstream/431045; ENST00000627910/Downstream/1074948;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/572105, chr13-CpG: 34/Downstream/1181340
Nearby gene
PCDH9(-573096) ; LINC00550(+1057853) ;
Upstream sequence
TCAGCCGACTAAAGAATTCAGTGTTTGCTCTCAGCAATTATTATGACGGATGGCTGCAGCACGCCATTGTTTTGTCTGCCTCGGAGGTGGTCGTGGCAAG
Downstream sequence
ACTGTCTCTGCTCCGGAGGGGTGTTTAGCTACATGTTTACAAAAGTGGCTAAGGCCTTAGGGATTAGATTTATCTCACAGTTAAAGGCAGCTTTTTCTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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