Basic Information
VIS ID
TVIS10012085
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr13
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
91024509/90372255 (Hg38)
End
91024509/90372255 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/140978; hsa-mir-1267/Downstream/978350;
Nearest TSS
ENST00000623511/Upstream/252536; ENST00000426840/Downstream/121032;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1008734, chr13-CpG: 49/Downstream/802740
Nearby gene
MIR622(-140978) ; LINC00410(+518699) ;
Upstream sequence
acaaggtcaggagtttgagaccagccaggccaacatagtgaaaccccgtctctactaaaaatacaaaaattagccaggcgtggtgatgggcacctgtaat
Downstream sequence
cccaggtactcaggaggctgaggcaggagaaagaattgcttgaacctgggaaggtggaggttgcagtgagccgggatggtgccattgcactccagcccag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate