Basic Information
VIS ID
TVIS10012092
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2402
Orient
+
Integrated sequence
CACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAG| |GTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTC
Host Sequence
Chromosome
chr18
Cytoband
q11.1
Reference genome
End
18519012/20939051 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3156-2/Upstream/6108809; hsa-mir-1-2/Downstream/744467;
Nearby gene
ROCK1(+10691) ;
Nearest cancer related gene
ROCK1(OG, +10691) ;
Upstream sequence
tcgaaatgtccacttccacatactacaaaaagagtgtttcaaaccttctctatgaaagggaatgttcaactctatgagttgaatgcaaacatcagaacga
Downstream sequence
aatttctgagaatgctgctgtccactttttatatgaatgcgcgctttcaacgaaatcctcaaagcaatccaaatatccacttgcagattccacaaaaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate