VISDB Viral Integration Site DataBase

VIS ID

TVIS10012093

Fusion event

HBV-OSBPL1A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1826

Orient

-

Integrated sequence

AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA

Chromosome

chr18

Cytoband

q11.2

Reference genome

Start

End

21968645/24388681 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-340-5p ; hsa-mir-146a-5p ; hsa-mir-21-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-6731-3p ; hsa-mir-4301 ; hsa-mir-6777-3p ; hsa-mir-3938 ; hsa-mir-7844-5p ; hsa-mir-5003-3p

Nearest miRNA

hsa-mir-1-2/Upstream/66935; hsa-mir-122/Downstream/2202786;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/116476, chr18-CpG: 75/Downstream/8630

Upstream sequence

ctgaggtcaggagttcgagagcagcttggacaacatggcgaaactccgtctctactaaaagtacaaaaattagccaggcgtggtgatgggcacctgtaat

Downstream sequence

cccagctactcaggaagctgaagcaggagaatcgcttgaacccaggaggtggaggctgcagtgagccaagatcgcgccactgcacttcagtctgggcgac