Basic Information
VIS ID
TVIS10012099
Fusion event
HBV-LINC01123 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
729
Orient
-
Integrated sequence
CGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGG| |CTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTAT
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
110746661/109989084 (Hg38)
End
110746661/109989084 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA2S
Target gene
LINC01123
Nearest miRNA
hsa-mir-1285-2/Upstream/675459; hsa-mir-10b/Downstream/80877;
Nearest TSS
ENST00000437798/Upstream/812; ENST00000456683/Downstream/126737;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/614, chr2-CpG: 29/Downstream/82800
Upstream sequence
atctaggagtgcaattgctatattatatggcaaccccgtgtttcactttttgacaaagtgccagactgcttttcaaaggacagcatcattttatattcct
Downstream sequence
gccagcaatgtcgaggggtccagtttccacacattctcacaaacacttattgttatctgtctctctagttattgccttcctgatggatgtggagtgcttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate