Basic Information
VIS ID
TVIS10012100
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
-
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
117934434/117176858 (Hg38)
End
117934434/117176858 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/3455490; hsa-mir-10b/Downstream/10246679;
Nearest TSS
ENST00000437798/Upstream/1362195; ENST00000489933/Downstream/627316;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2013669, chr2-CpG: 48/Downstream/637678
Nearby gene
DPP10(-1332108) ; DDX18(+637821) ;
Upstream sequence
ttcccaggctggagagcagtagtgcaatctcggctcactgcaacctccacctcctggattcaagcctttcttgtatctcagacccccaagtagctggaat
Downstream sequence
tacaggtgcccatcaccacgcctggctaatttttgtatttttagtagagatgaggttttgccatgttggcatggctggtttcgaactcctgacctcaggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate