Basic Information
VIS ID
TVIS10012101
Fusion event
HBV-LOC112268281 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17327777/15955457 (Hg38)
End
17327777/15955457 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
LOC112268281
Nearest miRNA
hsa-mir-10396a/Upstream/2231183; hsa-let-7c/Downstream/583632;
Nearest TSS
ENST00000624081/Upstream/27161; ENST00000602935/Downstream/115065;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/224973, chr21-CpG: 138/Downstream/1557031
Nearby gene
USP25(-75400) ; MIR99AHG(+115065) ;
Upstream sequence
cacacatgttggagtgccatggagtaatcttggttcactgcaacctccgcctcctgggtttaagcgattcttctgtctcagccttctgagtagctagaat
Downstream sequence
tacaggtgcccatcaccacgcctggctaatacttgtatttttagtagagaccaggttttgccatgttggccagcctgatcttgaactcctgacctcaggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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